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29.Gannett, C., Tiller, K., Briganti, A. J., Brown, A. M., Weger-Lucarelli, J., Lowell, A. N. “Forgotten natural products: Semisynthetic development of blasticidin S as an antibiotic lead” ACS Med. Chem. Lett. 202415(3), 362-368. DOI: 10.1021/acsmedchemlett.3c00527

28.Rivers, M. A. J., Lowell, A. N. “Expanding the biosynthetic toolbox: The potential and challenges of in vitro type II polyketide synthase research” SynBio20242(1), 85-111. DOI: 10.3390/synbio2010006


27.Singh, S., King, K., Gannett, C., Chuong, C., Joshi, S., Plate, C., Farzeen, P., Webb, E., Kunche, L. K., Weger-Lucarelli, J., Lowell, A. N., Brown, A. M., Deshmukh, S. “Data Driven Computational Design and Experimental Validation of Drugs for Accelerated Mitigation of Pandemic-Like Scenarios”. J. Phys. Chem. Lett. 202314(42), 9490-9499.  DOI: 10.1021/acs.jpclett.3c01749

26. Gannett, C., Banks, P., Chuong, C., Weger-Lucarelli, J., Mevers, E., Lowell, A. N. “Semisynthetic blasticidin S ester derivatives show enhanced antibiotic activity” RSC Med. Chem. 202314, 782-789. DOI: 10.1039/D2MD00412G    


25. Breiner, L. M., McCord, J. P., Briganti, A., Heifitz, M., Philbrook, S., Slebodnick, C., Brown, A. M., Lowell, A. N. “Triazoles as pharmacophores to explore sidechain functionalization for expanded pleuromutilin derivatives” Tetrahedron Chem. 2022, 4, 100034. DOI: 10.1016/j.tchem.2022.100034

24. McCord, J. P, Kohanov, Z. A., Lowell, A. N. “Thermorubin biosynthesis initiated by a salicylate synthase suggests an unusual conversion of phenols to pyrones.” ACS Chem. Biol. 2022, 17(11), 3169-3177. DOI: 10.1021/acschembio.2c00606


23. Breiner-Goldstein, E., Eyal, Z., Matzov, D., Halfon, Y., Cimicata, G., Baum, M., Ezernitchi, A., Lowell, A., Schmidt, J., Rokney, A., Zimmerman, E., Rozenberg, H., Bashan, A. Valinsky, L, Anzai, Y., Sherman, D. H., Yonath, A. “Ribosome-binding and anti-microbial studies of the mycinamicins, 16-membered macrolide antibiotics from Micromonospora griseorubidaNucleic Acids Res. 2021, 49(16), 9560-9573.  DOI: 10.1093/nar/gkab684

22. Hohlman, R. M., Newmister, S. A., Sanders, J. N., Khatri, Y. Li, S., Keramati, N. R., Lowell, A. N., Houk, K. N., Sherman, D. H. “Structural diversification of hapalindole and fischerindole natural products via cascade biocatalysis” ACS Catal. 2021, 11(8), 4670-4681.  DOI: 10.1021/acscatal.0c05656

21. KaKalkreuter, E., Bingham, K. S., Keeler, A. M., Lowell, A. N., Schmidt, J. J., Sherman, D. H., Williams, G. J. “Computationally-guided exchange of substrate selectivity motifs in a modular polyketide synthase acytransferase” Nat. Commun. 2021, 12(2193)  DOI: 10.1038/s41467-021-22497-2 and as a Preprint: biorxiv/2020.04.23.058214


20. Koch, A. A., Schmidt, J. J., Lowell, A. N., Hansen, D. A., Coburn, K., Chemler, J. A., Sherman, D. H. “Probing Selectivity and Creating Structural Diversity Through Hybrid Polyketide Synthases” Angew. Chem. Int. Ed. 2020, 59(32), 13575-13580.  DOI: 10.1002/anie.202004991

19. Khatri, Y., Hohlman, R., Mendoza, J., Li, S., Lowell, A. N., Asahara, H., Sherman, D. “Multicomponent microscale biosynthesis of unnatural cyanobacterial indole alkaloids” ACS Synth. Biol. 2020, 9(6), 1349-1360. DOI: 10.1021/acssynbio.0c00038

18. Li, S., Newmister, S. A., Lowell, A. N., Zi, J., Chappell, C. R., Yu, F., Hohlman, R. M., Orjala, J., Williams, R. M., Sherman, D. H. “Control of stereoselectivity in diverse hapalindole metabolites is mediated by cofactor-induced combinatorial pairing of Stig cyclases” Angew. Chem. Int. Ed., 2020, 59(21), 8166-8172.  DOI: 10.1002/anie.201913686 and as Preprint: chemrxiv/10032260


17. Kalkreuter, E., CroweTipton, J. M., Lowell, A. N., Sherman, D. H., Williams, G. J. “Engineering the Substrate Specificity of a Molecular Polyketide Synthase for Installation of Consecutive Non-Natural Extender Units” J. Am. Chem. Soc. 2019, 141(5), 1961-1969.  DOI: 10.1021/jacs.8b10521

16. Aroua, S., Lowell, A. N., Ray, A., Trapp, N., Schweizer, W., Ebert, M., Yamakoshi, Y. “Larger Substituents on Amide Cavitands Induce Bigger Cavities” Org. Lett. 2019, 21(1), 201-205.  DOI: 10.1021/acs.orglett.8b03660


15. Skiba, M. A., Sikkema, A. P., Moss, N. A., Lowell, A. N., Su, M., Sturgis, R. M., Gerwick, L., Gerwick, W. H., Sherman, D. H., Smith, J. L.  “Biosynthesis of t-Butyl in Apratoxin A: Functional Analysis and Architecture of a PKS Loading Module” ACS Chem. Biol. 2018, 13(6), 1640-1650.  DOI: 10.1021/acschembio.8b00252

14. Slocum, S. T., Lowell, A. N., Tripathi, A., Smith, J. L., Sherman, D. H. “Chemoenzymatic dissection of polyketide beta-branching in the bryostatin pathway” Meth. Enzymol. 2018, 604, 207-236. DOI: 10.1016/bs.mie.2018.01.034

13. Newmister, S. A., Li, S., Garcia-Borras, M., Sanders, J. N., Yang, S., Lowell, A. N., Yu, F., Smith, J. L., Williams, R. M., Houk, K. N., Sherman, D. H. “Structural basis of the Cope rearrangement and C-C bond-forming cascade in hapalindole/fischerindole biogenesis” Nature Chem. Biol. 2018, 14, 345-351.  DOI: 10.1038/s41589-018-0003-x  and as Preprint: biorxiv/173674


12. Lowell, A. N., DeMars II, M. D., Slocum, S. T., Yu, F., Anand, K., Chemler, J. A., Korakavi, N., Priessnitz, J. K., Hansen, D. A., Koch, A. A., Schultz, P. J., Sherman, D. H. “Chemoenzymatic diversification through late-stage polyketide assembly, tailoring, and C-H functionalization: The total synthesis of tylactone-based macrolide antibiotics” J. Am. Chem. Soc. 2017, 139(23), 7913-7920. DOI: 10.1021/jacs.7b02875

11. Li, S., Lowell, A. N., Newmister, S. A., Yu, F., Williams, R. M., Sherman, D. H. “Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids” Nature Chem. Biol. 2017, 13(5), 467-469. DOI: 10.1038/nchembio.2327

10. Koryakina, I., Kasey, C., McArthur, J. B., Lowell, A. N., Chemler, J. A., Li, S., Hansen, D. A, Sherman, D. H., Williams, G. J. “Inversion of extender unit selectivity in the erythromycin polyketide synthase by acyltransferase domain engineering” ACS Chem. Biol. 2017, 12(1) 114-123. DOI: 10.1021/acschembio.6b00732


9. DeMars II, M. D., Sheng, F., Park, S. R., Lowell, A. N., Podust, L. M., Sherman, D. H. “Biochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway” ACS Chem. Biol. 2016, 11(9), 2642-2654. DOI: 10.1021/acschembio.6b00479


8. Lowell, A. N., Santoro, N., Swaney, S. M., McQuade, T. J., Schultz, P. J., Larsen, M. J., Sherman, D. H. “Microscale Adaptation of in vitro Transcription/Translation for High Throughput screening of Natural Product Extract Libraries” Chem. Biol. Drug Des. 2015, 86(6), 1331-1338.  Editor’s choice and cover story. DOI: 10.1111/cbdd.12614

7. Li, S., Lowell, A. N., Yu, F., Raveh, A., Newmister, S. A., Bair, N., Schaub, J. M., Williams, R. M., Sherman, D. H. “Hapalindole/Ambiguine Biogenesis is Mediated by a Cope Rearrangement, C-C Bond-Forming Cascade” J. Am. Chem. Soc. 2015, 137(49), 15366-15369. DOI: 10.1021/jacs.5b10136


6. Lowell, A. N., Qiao, H., Liu, T., Ishikawa, T., Zhang, H., Oriana, S., Wang, M., Ricciotti, E., FitzGerald, G. A., Zhou, R., Yamakoshi, Y. “Functionalized Low-Density Lipoprotein Nanoparticles for in Vivo Enhancement of Atherosclerosis on Magnetic Resonance Images” Bioconjugate Chem. 2012, 23(11), 2313-2319. DOI: 10.1021/bc300561e


5. Yamakoshi, Y., Qiao, H., Lowell, A. N., Woods, M., Paulose, B., Nakao, Y., Zhang, H., Liu, T., Lund-Katz, S., Zhou, R.  “LDL-based Nanoparticles for Contrast Enhanced MRI of Atheroplaques in Mouse Models” Chem. Comm.  2011, 47(31), 8835-8837. DOI: 10.1039/C1CC10924C

4. Lowell, A. N., Fennie, M. W., Kozlowski, M. C. “Alternative Spiroketalization Methods Toward Purpuromycin: A Diketone Approach to Prevent Benzofuran Formation” J. Org. Chem. 2011, 76(16), 6488-6502. DOI: 10.1021/jo200399z

3. Bandichhor, R., Lowell, A. N., Kozlowski, M. C. “Alternative Spiroketalization Methods Toward Purpuromycin: A Hemiketal Conjugate Addition Strategy and Use of an Electron Rich Isocoumarin Precursor” J. Org. Chem. 2011, 76(16), 6475-6487. DOI: 10.1021/jo200398v


2. Lowell, A. N., Wall, P. D., Waters, S. P., Kozlowski, M. C. “Synthesis of Differentially Protected Isocoumarins” Tetrahedron, 2010, 66(30), 5574-5582. DOI: 10.1016/j.tet.2010.05.077


1. Lowell, A. N., Fennie, M. W., Kozlowski, M. C. “A Concise Synthesis of the Naphthalene Portion of Purpuromycin” J. Org. Chem.2008, 73(5), 1911-1918. DOI: 10.1021/jo7024114